Sunday, March 3, 2013

Mike Trout Contract Renwed By Angels For $510,000 Salary, Agent Unhappy

TEMPE, Ariz. -- The Los Angeles Angels renewed the contract of AL Rookie of the Year Mike Trout for $510,000, prompting an angry response from the outfielder's agent.

Craig Landis said his client was disappointed with the decision announced Saturday. The salary is $20,000 above the major league minimum.

"During the process, on behalf of Mike, I asked only that the Angels compensate Mike fairly for his historic 2012 season, given his service time," Landis said in a statement. "In my opinion, this contract falls well short of a `fair' contract and I have voiced this to the Angels throughout the process. Nonetheless, the renewal of Mike's contract will put an end (to) this discussion."

Trout has 1 year, 70 days of major league service and is likely to be eligible for arbitration after the 2014 season and for free agency after the 2017 World Series. Teams can renew the contracts of unsigned players on their 40-man rosters from March 2-11

"Mike, himself, does not wish to comment on this matter," Landis said. "As when he learned he would not be the team's primary center fielder for the upcoming season, Mike will put the disappointment behind him and focus on helping the Angels reach their goal of winning the 2013 World Series."

Speedy Peter Bourjos is set to be the Angels' primary center fielder, flanked by Trout in left and 2010 AL MVP Josh Hamilton in right.

Trout had a $482,500 salary last year, when he finished second to Detroit's Miguel Cabrera in AL MVP voting. Trout hit .326 with 30 homers and 83 RBIs, and led the majors with 129 runs and 49 steals.

He also earned a $10,000 bonus for winning Rookie of the Year.

Los Angeles also agreed to one-year deals with 21 players, including Bourjos and Mark Trumbo.

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Source: http://www.huffingtonpost.com/2013/03/02/mike-trout-contract-angels_n_2799018.html

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Violence spreads in Borneo as five Malaysian police killed

LAHAD DATU, Malaysia (Reuters) - Gunmen have killed five policemen in Malaysia's Sabah state where members of an armed faction from the Philippines have been facing off with security forces as they stake an ancient claim to the remote corner of Borneo island.

Police on Friday tried to end the standoff with scores of followers of the sultan of Sulu, a south Philippine region, who occupied a Sabah village in February to press their claim. Two policemen and 12 followers of the sultan were killed.

The killing of the five policemen late on Saturday, in an ambush on police hunting followers of the sultan, will reinforce fears that insecurity is spreading in a region rich in resources that has been of increasing interest to investors.

Malaysia's inspector general of police, Ismail Omar, tried to ease any worries on Sunday, saying the situation was under control.

"I don't want speculation that Sabah is in crisis," Ismail told a news conference in the town of Lahad Datu. "We have our security forces at three places to respond."

The confrontation had threatened to reignite tension between the Philippines and Malaysia. Ties have been periodically frayed by security and migration problems along their sea border.

Economic interests are also at risk.

Oil majors like ConocoPhillips and Shell have poured in large sums to develop oil and gas fields in Sabah. Chinese companies have been investing in hydro-power and coal mining.

Much of Borneo's forest has been cleared, to the horror of indigenous people and environmentalists, and replanted with palm oil. Tens of thousands of migrants have come to Sabah from the Philippines to clear the timber and work the plantations.

For generations Borneo, one of the worlds' biggest islands, was a forbidding expanse of jungle, thinly populated by head-hunting tribesmen, and claimed by Muslim sultans and later European colonialists based in coastal trading towns.

"DRASTIC ACTION"

Colonial Britain and the Netherlands carved up the island in the nineteenth century and Malaysia and Indonesia took their shares upon independence. Britain agreed to independence for the tiny oil-rich sultanate of Brunei on Borneo's west coast.

But under a pre-colonial pact between sultans, Sulu, in what would later become the Philippines, was awarded control of the northern corner of Borneo, in what would later become Malaysia.

A British trading company agreed during colonial times to pay Sulu a nominal lease for Sabah - it now amounts to 5,300 ringgit ($1,700) a year - and the claim of the ancient Sulu sultanate on Sabah was all but forgotten, until February.

Then, about 150 followers of the Sulu sultanate, which has no power but commands respect in the southern Philippines, sailed in and occupied a Sabah village, staking their claim and demanding a renegotiation of Sabah's lease.

Malaysia has said the demands will not be met and has sent in the security forces. Both Malaysia and the Philippines have called on the gunmen to give up and go home.

An increasingly exasperated Malaysian prime minister, Najib Razak, who faces an election in weeks, has promised "drastic action" if the group does not leave.

The trouble looks to be at least partly the result of efforts to forge peace in the southern Philippines, in particular a peace deal signed between the Philippine government and Muslim rebels last October to end a 40 year conflict.

Jamalul Kiram, a former sultan of Sulu and brother of the man Philippine provincial authorities regard as sultan, said the peace deal had handed control of much of Sulu to Moro Islamic Liberation Front (MILF) rebels, ignoring the sultanate.

The sultan loyalists had gone to Malaysia to revive their claim to Sabah as a protest in response to what they saw as the unfair peace deal, he said.

A senior Malaysian defense official said the gunmen in Sabah had links with a Philippine rebel faction leader called Nor Misuari, who also saw no benefit from the pace deal.

"He will surely stir up more trouble," said the Malaysian official, who declined to be identified.

(Reporting by Niluksi Koswanage in KUALA LUMPUR; Additional reporting by Manuel Mogato in MANILA; Editing by Robert Birsel)

Source: http://news.yahoo.com/violence-spreads-borneo-five-malaysian-police-killed-080154499--finance.html

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Lots of hand made bird breeder cages | Crowley | eBay Classifieds ...

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Source: http://acadiana.ebayclassifieds.com/birds/crowley/lots-of-hand-made-bird-breeder-cages/?ad=26571561

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Friday, March 1, 2013

Study shows key enzyme missing from aggressive form of breast cancer

Friday, March 1, 2013

A new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain ? providing insight into potential therapeutic targets to treat the aggressive cancer. Zhou's study is unique in that his lab is the only one in the country to specifically study the metabolic process of triple-negative breast cancer cells.

Normally, all cells ? including cancerous cells ? use glucose to initiate the process of making Adenosine-5'-triphosphate (ATP) for fuel to carry out essential functions. This process, called glycolysis, leads to other processes that use oxygen to make higher quantities of ATP ? but solid tumor cells, which have little access to oxygen, are forced to rely almost exclusively on aerobic glycolysis for survival.

Zhou's study, published in Cancer Cell, showed that the powerful transcription factor complex Snail-G9a-Dnmt1 is over-expressed in triple-negative breast cancer, inhibiting the enzyme 1,6-bisphosphate (FBP1). The loss of this enzyme shuts down the glucose anabolic pathway and promotes the glucose catabolic pathway, leading to a large amount of glucose entering the tumor cells and thus "feeding" the aggressive cancer. This metabolic switch empowers the triple-negative breast cancer cells to suck more glucose from the body, increasing macromolecule biosynthesis in tumor cells and maintaining ATP production despite a dearth of nutrients and an oxygen-free environment.

Triple-negative breast cancer is the most deadly subtype of breast cancer, and tends to occur in women at a younger age. This subtype of breast cancer has poor clinical outcomes due to the early metastasis of tumor cells, resistance to chemotherapy, and the lack of specific drugs that target it. Identifying this change in the cancer's metabolic process provides major insight into developing drugs to target the disease, Zhou says.

"These findings present significant insights regarding the development and progression of triple-negative breast cancer," said Zhou, associate professor of molecular and cellular biochemistry at UK. "They indicate that targeting the metabolic alteration will lead to an effective approach for treating this deadly disease."

Zhou's research was aided by the team in the Free Radical Biology in Cancer Shared Resource Facility (FRBC) of the Markey Cancer Center, directed by Dr. Allan Butterfield. The FRBC used an instrument called the Seahorse XF-96 Flux Analyzer to test and confirm the predictions of Zhou's findings in triple-negative breast cancer.

"The significance of this study rests in proving that triple negative breast cancer cells utilize glycolysis for survival and growth," Butterfield said. "The FRBC will assist Dr. Zhou in furthering this exciting research, potentially helping to identify key proteins in triple negative breast cancer cells that are expressed or modified differently than in control cells. Such knowledge may lead to new insights to potential approaches to treat this aggressive cancer."

###

University of Kentucky: http://www.uky.edu

Thanks to University of Kentucky for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127084/Study_shows_key_enzyme_missing_from_aggressive_form_of_breast_cancer

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Seven Things You Didn't Know About... Exorcisms

By Tara Fowler Poor Nell Sweetzer just can't seem to catch a break. This weekend sees the opening of "The Last Exorcism: Part II," in which the evil that haunted Nell in the first film returned for, well, round two. Worried the same will happen to you? Never fear! We decided to educate ourselves on [...]

Source: http://moviesblog.mtv.com/2013/02/28/seven-things-you-didnt-know-about-exorcisms/

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Cousineau Family Blog: Dying, Death and Going Home

I was on Facebook and saw a post about my dear friend Suzie. ?She has cancer. ?And just a few days before my other friend came to visit me and informed me that she also has cancer. It got me to thinking about our lives and mortality, as I think these things always do. ?It also made me?realize?that I have been lax in my duties as a friend to all my friends in Massachusetts and to those that have moved on to other places. ?So to start I am posting on this blog to let?people?know that I have not forgotten them. I just let life get away from me. ?And I didn't take time to stop and remember what is most important, which is the people in my life.

I don't want my friends to leave, but I'm grateful that they will be out of pain and with their Heavenly Father and families again. They will be happy then. And I will do my best to be happy for them. It's the right thing to do to think of their needs over my own.

Other stuff not related to the title:

I have started a book club in my ward. I have informed people of $3 date night at the cheap theater, and I have started a game night. ?All these idea's are compliments of the wonderful women of the Ludlow Ward. ?I miss you all very much. ?I think of you every?Tuesday?as I participate in these?activities. (I don't know what Jason thinks, I didn't ask him.)

I saw the most beautiful sunset, I couldn't get a picture of it though. ?But imagine with me. ?The horizon has tiny purple mountains, they appear to be 2" tall, but are in reality about 5000ft above sea level. Skimming to tops of the mountains is a shimmery red-orange light, with tiny touches of yellow, from the setting sun. And then above that purple clouds, puffy and thick, not promising a storm, but blue skies ahead. ?It had to be the most beautiful sunset I have ever seen. ?I wish I had the ability to take that picture from my mind and put it on this blog. ?Because it is more beautiful than words can say.

Another unrelated topic:



Source: http://cousineaufamilyblog.blogspot.com/2013/02/dying-death-and-going-home.html

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